Antioxidant Status and Cytogenetic Injury
György J. Köteles1, Iván Bojtor1, Gabriella Bognár1, and Miklós Ótós2
1 “Frédéric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene, József Fodor National Centre for Public Health, Budapest, Hungary
2 Atommed Ltd., Paks, Hungary
Corresponding author: Prof. György J. Köteles
“Frédéric Joliot-Curie” National Research Institute
for Radiobiology and Radiohygiene
P.O. Box 101
H-1775 Budapest, Hungary
Telephone: (36 1) 229 19 26
Fax number: (36 1) 229 19 26
E-mail adress: radbiol@hp.osski.hu
CEJOEM 2001, Vol.7. Nos.3-4.:217-227
Key words:
Low dose, lymphocyte micronuclei, antioxidant protection
Abstract:
The individual responses of 77 persons were studied in vitro by lymphocyte micronucleus
assay following X-irradiations of 0.7 and 0.25 Gy. The influence of antioxidant consumption on
the total antioxidant status (TAS) was studied in a group of 155 individuals. Linear correlations
of different correlation coefficients (R) were found between the increment and the normal total
antioxidant level (TAS value) of the donors' sera: the higher was the antioxidant status, the less
was the yield of radiation-induced micronucleus increment. The cytogenetic effect of low doses
could be significantly protected above appr. 1.6 mmol·L-1 of TAS. Accordingly, the resistance in
population, as it were, could be increased by long-lasting consumption of vitamins C and E, i.e.,
the initial TAS values must have been elevated. The data seem to give sufficient reason to confirm
that proper health conditions significantly lower the risk level even in low dose range.
Received: 30 July 2001
Accepted: 06 November 2001
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