The Effect of Ionizing Radiation on the Antioxidant Capacity of the Human Blood
Gabriella Bognár, Gabriella Mészáros and György J. Köteles
Frédéric Joliot-Curie National Research Institute for Radiobiology and Radiohygiene,
József Fodor National Center for Public Health, Budapest, Hungary
Corresponding author: Gabriella Bognár
Frédéric Joliot Curie NRIRR, József Fodor National Center for Public Health
Anna u. 5
H-1221 Budapest, Hungary
Telephone: (+36) 1 226 0026, (+36) 1 226-6974
Fax number: (+36) 1 226 6531
E-mail: E-mail: bognar@hp.osski.hu
CEJOEM 2000, Vol.6. No.4.:300-305
Key words:
Antioxidant capacity, GPx, SOD, human plasma, ionising radiation
Abbreviations:
GPx = glutathione peroxidase
SOD = superoxide dismutase
TAS = total antioxidant status
Abstract:
The total antioxidant capacity, activities of antioxidant enzymes like glutathione peroxidase (GPx) and superoxide dismutase (SOD) and the effect of ionizing radiation on these antioxidants in human blood were measured by the RANDOX assays. The different doses of ionizing radiation caused dose-dependent decreases of antioxidant activities. The total antioxidant status (TAS) value of plasma linearly decreased up to 1 Gy dose. At higher dose (2 Gy), no additional decrease of TAS value could be detected. Radiation-induced decrease of the antioxidant enzymes GPx and SOD were linear up to 1 Gy dose. Between 1 and 2 Gy doses, a further mild decrease could be detected.
Received: 20 October 2000
Accepted: 13 December 2000
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