CEJOEM 1999 5(2):181-191
ABSTRACT: Characterizing processes of transport within
dynamic systems in terms of kinetics is difficult. A possible approach
to this problem was exemplified by a re-analysis of in vivo kinetic
data of propylene in rats exposed in a closed chamber using a compartment
model. Based on a two-compartmental model and assuming first-order kinetics,
a recently developed statistical approach using acceleration information
and nonlinear regression was applied to investigate the kinetic processes
of propylene inhaled by male Sprague-Dawley rats. This approach is based
on characteristics of systems of mathematical first order differential
equations and allows to detect and to characterize deviations from the
usually made first-order kinetics assumption.
KEY WORDS: Propylene, toxicokinetics, animal experiment, inhalation study
| Received: 31 December 1999
Accepted: 16 July 1999 Posted: December 1999 |
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