Combined Pulmonary Toxicity of Diethyldithiocarbamate and Lead(II)oxide
in Rats
E. Tátrai1, M. Náray1, M. Brózik2,
Z. Adamis1, T. Kerényi3, and Gy. Ungváry1
1National Institute of Occupational Health, Budapest, Hungary
2Semmelweis University Medical School, Central Immunological
Laboratory, Budapest, Hungary
3Semmelweis University Medical School, 2nd Department of
Pathology, Budapest, Hungary
CEJOEM 1997, Vol.3. No.4.:336
The pulmonary toxicity of sodium diethyldithiocarbamate and lead(II) oxide
alone or in combination was studied in rats after a single intratracheal
instillation. The lead content in the lungs and the whole blood was determined
and it has been found that the clearance of lead from the lungs was delayed
by dithiocarbamate complex formation, which probably had a role in increased
IgA levels in the bronchoalveolar fluid and the induction of the local
immune response. The combined exposure gave rise to calcium deposits in
the lungs both extra- and intracellularly after 1 month of exposure. Both
separate and combined exposure invoked permanent injury in membranes or
dystrophic changes in the cytoplasm of pneumocytes, which may initiate
and generate the events leading to fibrosing alveolitis.
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