Antioxidant Treatment of Radiation Injuries

Nikoghos Oganesian1, Ingrid Emerit2, Artashes Pogosian1, Armenuhi Abramian1, Ruben Arutyunian3, Karine Asrian1, Tamara Sarkisian3 and Ararat Esayan1

1Scientific Center of Radiation Medicine and Burns, Ministry of Health, Yerevan, Armenia;
2Institute Biomedical des Cordiliers, Universite Pierre et Marie Curie, Paris;
3State University of Armenia.
 
Corresponding author: Nikoghos Oganesian
Director of Research Center
Scientific Center of Radiation Medicine and Burn, Ministry of Health
375078 Yerevan, Davidashen p/b 25 Armenia

CEJOEM 1997, 3:125-131


Key words:
Chernobyl, radiation injuries, antioxidants, clinical status, lipid peroxidation, clastogenic factor, chromosome aberrations

Abbreviations:
AO – antioxidant;
AOB – antioxidant biofactor;
CA – clastogenic activity;
CF – clastogenic factor;
CPP – Chernobyl power plant;
ECG – electrocardiogram;
EEG – electroencephalogram;
IEL – induced enzyme LPP;
INL – induced non-enzyme LPP;
L – Loshtak;
LPP – lipid peroxidation;
NADF-H – nicotine-amid dinuclide phosphate;
NS – nervous system;
T – Tanakan®;
T3 – triotirozine;
T4 – tiroxin;
TTG – tireotropin.


Abstract:
Observations on the health status of 2200 persons working at the Chernobyl site after the accident – “liquidators” – supervised and treated in our Center for 10 years have been summarized. A rise of morbidity several years after the accident was observed, mainly a gradual transition of functional pathological alterations into organic ones, mostly of the nervous and cardiovascular systems, respiratory organs, gastrointestinal tract. Long-term monitoring could reveal the decrease of the levels of chromosome aberrations, the persistence of the “clastogenic factor”, the level of spermatogenesis, and lipid peroxidation. The effects of antioxidants are described on the lipid metabolism and peroxidation as well as on the level of clastogenic factor following the treatment with antioxidant preparations like alpha-tocopherol, AscorutineR, AevitR, and LoshtakR.
Received: 07 January 1997
Accepted: 05 May 1997

Posted: 29 November 1998

| Back |