Adaptive Response of Gamma-Irradiated Lymphocytes in Human Population
Gabriella Bognár1, Katalin Szalma1, Miklós Ótos2, and György J. Köteles1
1 “Frédéric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene, Budapest, Hungary
2 Atommed Ltd. Paks, Hungary
Corresponding author: Dr. Gabriella Bognár
“Frédéric Joliot-Curie” National Research Institute for Radiobiology and Radiohygiene
POB. 101
H-1775 Budapest, Hungary
Telephone: (+36-1) 482-2000/121
E-mail: bognar@hp.osski.hu
CEJOEM 2007, Vol.13. No.1.: 25–31
Key words:
Ionizing radiation, adaptive response, human lymphocytes, individual sensitivity
Abstract:
Adapted responses were studied in human lymphocytes from blood samples of 133 men of 21–56 years.
Gamma-irradiation with 20 mGy conditioning dose and 1 or 2 Gy challenging doses were performed. The time
elapsed between the two doses was 1 hour. For endpoint cytokinesis-blocked lymphocyte micronuclei were
used. The frequencies were scored in 1000 cells per person and the radiation-induced increments were
compared to self-control values. It was found that the lymphocytes of all the persons investigated
responded by various extent of decrease of the harm – between 10 and 45 per cent – compared to the effect
of large doses only. Accordingly “low” and “high” responding persons could be distinguished. A slight
tendency of relationship was observed between the extent of adaptive response and the response of cells
to the large dose only. No age dependence of adaptive response was found in this group.
Received: 14 March 2007
Accepted: 28 May 2007
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