Antimicrobial Activity of Copper(II) Complexes with some Benzimidazole Derivatives against Microorganisms Widely Distributed in the Environment
Sanja O. Podunavac-Kuzmanović and Siniša L. Markov
Faculty of Technology, University of Novi Sad, Novi Sad, Serbia
Corresponding author: Sanja Podunavac-Kuzmanović, Ph.D.
Faculty of Technology
University of Novi Sad
Bulevar Cara Lazara 1
21000 Novi Sad, Serbia
Telephone: +381 21 6350 122/589
Fax number: +381 21 450 413
E-mail: sanya@uns.ns.ac.yu
CEJOEM 2006, Vol.12. No.1.: 61–66
Key words:
Copper(II), benzimidazoles, complexes, antimicrobial activity
Abstract:
The paper presents antimicrobial investigations of copper(II) complexes with two series of
benzimidazoles. The first one was based on 2-methylbenzimidazole, the second one contained
2-aminobenzimidazole. Antimicrobial activities of the ligands and their complexes were evaluated against
three Gram-positive bacterial strains (Bacillus sp., Staphylococcus aureus and Sarcina
lutea) one Gram-negative isolate (Pseudomonas aeruginosa), and yeast (Candida pseudotropicalis).
The majority of the investigated compounds displayed in vitro antimicrobial activity against very persistent
microorganisms. None of the compounds was significantly effective against yeast Candida
pseudotropicalis. Minimum inhibitory concentration (MIC) was determined for all ligands and their
complexes. The effect of ligand and complex structure on the antimicrobial activity is discussed.
Received: 5 December 2005
Accepted: 31 July 2006
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