Epithelial Irritation Effect of 1-Bromopropane,
an Alternative Solvent to Chlorofluorocarbons
Ágnes Pálovics
Department of Experimental Occupational Hygiene, National Institute of Occupational Health, József Fodor National Center for Public Health, Budapest, Hungary
Corresponding author: Ágnes Pálovics
Department of Experimental Occupational Hygiene
National Institute of Occupational Health
József Fodor National Center for Public Health
P.O. Box 22
H-1450 Budapest, Hungary
Telephone: +361 476 11 00/2565
Fax number: +361 216 99 07
E-mail: palovics@fjokk.hu
CEJOEM 2004, Vol.10. No.4.: 333–337
Key words:
1-Bromopropane, acute dermal irritation, rabbit, skin, local effects, HET-CAM
Abstract:
Irritation effect of 1-bromopropane was tested on the chorioallantois membrane of hen’s eggs and
on the skin of rabbits. Local application of the substance caused copious haemorrhage and moderate
lysis of blood vessels in the chorioallantois membrane of hen’s eggs and reversible damage (erythema,
oedema) to the rabbit’s skin. Complete regeneration of the skin took place in 8 days. On the basis of
both models 1-bromopropane proved to be irritative to the skin and is likely to be irritative to the
eye and the mucous membranes of the respiratory system.
Received: 22 June 2004
Accepted: 5 January 2005
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